Adding a certain compound to certain chemical reactions, such as: 213265-83-9, 4,6-Dichloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 213265-83-9, blongs to pyrimidines compound. category: pyrimidines
0.61 G OF sodium hydride (60% oil suspention) was suspended in 20 ml of tetrahydrofuran. 1 ml of tetrahydrofuran solution of 0.73 G OF 2-BUTYN-1-OL was added dropwise at 0C therein, and the mixture was stirred for 10 minutes. Into the mixture was added dropwise 5 ml of tetrahydrofuran solution of 1.75 g of 4,6-dichloro-5-fluoropyrimidine, and stirred for 90 minutes at 0C. The reaction mixture was poured into a saturated ammonium chloride aqueous solution, and the mixture was extracted with TERT-BUTYL methyl ether three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 1.8 g of 4- (2-BUTYNYLOXY)-6-CHLORO-5-FLUOROPYRIMIDINE. 1H-NMR : 1.79 (t, 3H), 5.00 (q, 2H), 8.29 (s, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,213265-83-9, its application will become more common.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2004/99160; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia