Reference of 7627-44-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine. A new synthetic method of this compound is introduced below.
Step 5: Intermediate 5 [00557j To a 125 mL tube was added Intermediate 4 (360 mg, 1.60 mmol) 2,4-dichloro-5- (iodomethyl)pyrimidine (461 mg, 1.60 mmol) and DIPEA (848 tl, 4.79 mmol) in DMA (4 mL). The tube was sealed and the reaction mixture heated to 65 °C with stirring for 4 h after which it was cooled, concentrated and co-evaporated with toluene several times. The resultant oil was dissolved in EtOAc, and solids were removed by filtration. The filtrate was concentrated, dissolved in DCM and purified through flash chromatography on silica gel (eluting with EtOAc/hexanes) to provide 350 mg of the title compound. MS mlz: 350.3 (M+Hj.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7627-44-3, 2,4-Dichloro-5-(iodomethyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; SANOFI; D’AGOSTINO, Laura Akullian; SJIN, Robert Tjin Tham; NIU, Deqiang; MCDONALD, Joseph John; ZHU, Zhendong; LIU, Haibo; MAZDIYASNI, Hormoz; PETTER, Russell C.; SINGH, Juswinder; BARRAGUE, Matthieu; GROSS, Alexandre; MUNSON, Mark; HARVEY, Darren; SCHOLTE, Andrew; MANIAR, Sachin; WO2014/144737; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia