Electric Literature of 6693-08-9, Adding some certain compound to certain chemical reactions, such as: 6693-08-9, name is 2,4,6-Trichloro-5-fluoropyrimidine,molecular formula is C4Cl3FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6693-08-9.
1 1(S)-5-Fluoro-W4-(1 -(5-fluoropyridin-2-yl)ethyl)-yV2-(2-methoxypyridin-3-yl)-6- morpholinopyrimidine-2,4-diamine a) 4-(2,6-Dichloro-5-fluoropyrimidin-4-yl)morpholineA solution of morpholine (1 .5 mL, 17.05 mmol) in ethanol (25 mL) was added to a cooled (-20 C) solution of 2,4,6-trichloro-5-fluoropyrimidine (3.00 g, 14.93 mmol) in ethanol (150 mL) and the resulting mixture was stirred at -20 C for 30 minutes and at ambient temperature for 3 hours. The solvent was evaporated under reduced pressure and the residue was partitioned between water and methylene chloride. The organic layer was separated, dried and the solvent evaporated under reduced pressure. The resulting white solid was triturated with ethanol, then filtered and dried to give the title compound (2.0 g, 53%).LRMS (m/z): 252/254 (M+1 )+.1H-NMR delta (CDCIs): 3.77-3.80 (m, 4H), 3.82-3.85 (m, 4H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; BACH TANA, Jordi; PAGES SANTACANA, Lluis Miquel; WO2013/17461; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia