As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 3764-01-0
Under nitrogen atmosphere, 2,4,6-trichloropyrimidine (40.0g, 0.218mol) and phenylboronic acid (26.6g, 0.218mol) completely dissolved in 250mL of tetrahydrofuran, was added 2M aqueous potassium carbonate solution (125mL) and tetrakis(triphenylphosphine)palladium (7.6g, 6.5mmol) then heated and stirred for 5 hours. The temperature was lowered to room temperature, the aqueous layer is removed, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and treated with a column with 1:3 ratio of tetrahydrofuran and hexane to prepare the compound 6-A (40g, yield: 82%).
With the rapid development of chemical substances, we look forward to future research findings about 3764-01-0.
Reference:
Patent; LG Chem, Ltd.; Xu, Dongxu; Li, Dongxun; Li, Xiangbin; Zhang, Junqi; Jin, Xingzhao; (67 pag.)CN105579445; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia