Reference of 1099597-81-5 ,Some common heterocyclic compound, 1099597-81-5, molecular formula is C11H5Cl2FN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Intermediate 46: 2,4-difluoro-6-(phenylmethyl)pyrimidineUnder an atmosphere of nitrogen, a solution of (2,6-dichloro-4-pyrimidinyl)(4- fluorophenyl)methanone (13.5g, 49.8mmol) in dichloromethane (4mL) was treated with diethylaminosulfur trifluoride (16mL, 121 mmol) and the mixture was stirred at ambient temperature for 20 hours. The mixture was then cautiously added dropwise to 1 OmL of ice/water and the product extracted with dichloromethane (2 x 1 OmL). The combined organic fractions were evaporated to dryness and passed through a short silica (Merck- 60) column (cyclohexane as eluent). Product-containing fractions were combined and evaporated to dryness to afford the title compound (12.4g, 42.3mmol, 85% yield). LCMS (Method A): Rt 1.20 minutes; no mass ion detected. 1H NMR (400MHz, CDCI3); delta 7.16 (2H, t, J=8.66Hz), 7.62 (2H, dd, J=8.78Hz, 5.27Hz), 7.68 (1 H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1099597-81-5, its application will become more common.
Reference:
Patent; GLAXO GROUP LIMITED; ALDER, Catherine, Mary; BALDWIN, Ian, Robert; BARTON, Nicholas, Paul; CAMPBELL, Amanda, Jennifer; CHAMPIGNY, Aurelie, Cecile; HARLING, John, David; MAXWELL, Aoife, Caitriona; SIMPSON, Juliet, Kay; SMITH, Ian, Edward, David; TAME, Christopher, John; WILSON, Caroline; WOOLVEN, James, Michael; WO2010/106016; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
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