Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2915-16-4, name is 2-Chloro-4,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Chloro-4,6-diphenylpyrimidine
To a 1 L flask was placed 11- (3- (dibenzo [b, d] furan-4-yl) phenyl) – 11,12-dihydroindolo [2,3- a] – carbazole (20 g), sodium hydride 4.8 g) and toluene (300 ml), and the mixture was stirred at 40 C. under a nitrogen atmosphere. After 1 hour, 2-chloro-4,6-diphenyl-1,3-pyrimidine (12.8 g) was added and stirring was continued at 80 F.The reaction was monitored by thin layer chromatography. After the reaction was completed, the reaction mixture was quenched with water (200 ml) and extracted using ethyl acetate (150 ml). The organic layer was extracted with water (3 ¡Á 100 ml) and dried over anhydrous sodium sulfate. For further purification, the collected ethyl acetate layer was passed through Celite column chromatography. Subsequently, the ethyl acetate layer was evaporated and dried under reduced pressure using a rotary evaporator. 100 ml of n-hexane was added, filtrated, and reduced pressure The residue was further precipitated by drying. As a yellow solid, 18 g (85%) of Compound F5 having an HPLC purity of 99% or more was obtained.
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Reference:
Patent; E-RAY OPTOELECTRONICS TECHNOLOGY COMPANY LIMITED; BALAGANESAN, BANUMATHY; HUANG, HEHLUNG; GUO, HUNG MING; HSU, POWEI; (23 pag.)JP2017/31112; (2017); A;,
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