Electric Literature of 1032452-86-0 ,Some common heterocyclic compound, 1032452-86-0, molecular formula is C13H10ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
P-Toluenesulfonic acid hydrate (22.73 g, 119.5 mmol)Was added to a solution of 3- (2-chloropyrimidin-4-yl) -1-methyl-indole (Intermediate 20, 24.27 g, 99.58 mmol)And 4-fluoro-2- (methyloxy-d3) -5-nitroaniline (Intermediate 21, 18.54 g, 99.58 mmol)In a mixture of 2-pentanol (500 mL).The resulting mixture was stirred at 105 C for 2.5 hours.Then cooled to room temperature. The resulting precipitate was collected by filtration,Washed with 2-pentanol (50 mL)Dried under vacuum to give some desired product as a yellow solid.The filtrate was cooled, the resulting precipitate was collected by filtration,Washed with 2-pentanol (10 mL). The two batches of products were combined,Grinding with CH3CN gave a solid which was collected by filtration,And dried under vacuum to give the title compound (37.4 g, 95%) as a yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1032452-86-0, its application will become more common.
Reference:
Patent; Jiao Yuqi; (53 pag.)CN107043369; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia