Related Products of 375857-62-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 375857-62-8, name is 3-Bromo-7-methylimidazo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
Finally, the compound of the formula (I) obtained above (323 mg, 1.0 mmol) was added to a 100 ml Schlenk tube.Then Pd(OAc)2 (purchased from Strem) (11.22 mg, 0.05 mmol) as a catalyst, DavePhos as a ligand was added.(2-Dicyclohexylphosphino-2′-(N,N-dimethylamine)-biphenyl, available from Strem) (39.354 mg, 0.1 mmol) and as a baseCs2CO3 (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) (358.82mg, 1.1mmol), and the Schlenk tubeFill the vacuum line with argon three times. Then, under an argon atmosphere, add to the Schlenk tube.3-bromo-7-methylimidazo[1,2-A]pyrimidine (purchased from Shanghai Bi De Pharmaceutical Technology Co., Ltd.) (233.75 mg, 1.1 mmol), then addedN,N-dimethylacetamide (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) (1.0 ml), and the reaction was stirred at room temperature for 4 hours.After the reaction was completed, the reaction mixture was washed with brine and extracted with ethyl acetate.Dry over sodium sulfate and evaporate to dryness on a rotary evaporator. Finally, it was separated through a silica gel column (eluent: petroleum ether: ethyl acetate: 4:1) to afford the compound of formula 7 as a white solid, yield 78%.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 375857-62-8, 3-Bromo-7-methylimidazo[1,2-a]pyrimidine.
Reference:
Patent; University of Science and Technology of China; Xiao Bin; Wang Guofu; Song Haijie; (17 pag.)CN108715593; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia