Sources of common compounds: 33034-67-2

According to the analysis of related databases, 33034-67-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 33034-67-2, Adding some certain compound to certain chemical reactions, such as: 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine,molecular formula is C5H2ClF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33034-67-2.

Stir a mixture of (S)-(2,4-dichlorobenzyl)-pyrrolidin-3-ylamine (266 mg5 1 mmol), 2-chloro-4-(trifluoromethyl)-pyrimidine (365 mg, 2 mmol) and polymer supported potassium carbonate (626 mg, 2 mmol) at 8O0C overnight. Filter away the EPO polymer and pour the filtered reaction mixture onto a SCX-2 column. Elute with methanol and then elute with 2 M ammonia in methanol. Concentrate to give a residue and chromatograph on silica gel to give the title compound (258 mg, 66percent). Prepare the hydrochloride salt essentially as described in EXAMPLE 1 to give the hydrochloride salt of the title compound. 1H NMR (400 MHz, MeOH-O4) delta 8.39 (2H, m), 7.71 (IH, d, J = 8.56 Hz), 7.68 (IH, d, J = 1.71 Hz)5 7.51 (IH, dd, J = 8.31, 1.96 Hz), 4.46-4.55 (2H, m), 4.19-4.26 (IH, m), 4.09-4.14 (IH, m), 3.89-3.98 (2H, m), 3.73 (IH, m), 2.63-2.70 (IH, m), 2.39-2.48 (IH, m), MS (ES): m/z = 391[M+].

According to the analysis of related databases, 33034-67-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/44454; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia