With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3438-48-0, name is 4-Phenylpyrimidine, molecular formula is C10H8N2, molecular weight is 156.18, as common compound, the synthetic route is as follows.Recommanded Product: 3438-48-0
General procedure: To the mixture of an appropriate 4-substititedphenylpyrimidine (0.06mol) and acetamide (500mL), concentrated sulfuric acid (20mL) was added drop-wise at the temperature of 0-10C. Upon the completion of addition, 30% H2O2 (50mL) and saturated FeSO4·7H2O (aq. 100mL) were added drop-wise at the same time at the temperature of 0-10C. The reaction mixture the was stirred at 10-15C for 0.5h and then poured into water (2000mL), basified with potassium hydroxide to pH 9, and extracted with dichloromethane (200mL×3). The combined extracts were washed with brine (200mL×2), dried over anhydrous Na2SO4, and concentrated in vacuum to give the corresponding 4-substititedphenylpyrimidine-2-carboxamides as white solids in a moderate yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3438-48-0, 4-Phenylpyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Tang, Qidong; Zhao, Yanfang; Du, Xinming; Chong, Lian’E; Gong, Ping; Guo, Chun; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 77 – 89;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia