Related Products of 347418-42-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 347418-42-2, name is 4-Chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
2,4-Dichloro-5-fluoropyrimidine (7, 0.37 g, 2.2 mmol), sodium carbonate (0.42 g, 4 mmol) dissolved in 1,4-dioxane/water (10 mL / 2 mL) Add bistriphenylphosphine palladium dichloride (Pd(PPh3)2Cl2, 0.033g, 0.048 mmol) under nitrogen, heat to 80 C, add 1-isopropyl-4-fluoro-6-borate A solution of the alcohol ester-1H-carbazole (6a, 0.5 g, 1.6 mmol) in 1,4-dioxane (10 mL). The reaction 80 4 hours, the reaction was cooled to room temperature, poured into ice water (50 mL), the precipitated white solid was filtered to give the residue, recrystallized from isopropanol, to give a white solid 8a (0.4 g, 81%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 347418-42-2, 4-Chloro-5-fluoropyrimidine.
Reference:
Patent; Hangzhou Bai Cheng Pharmaceutical Technology Co., Ltd.; Sheng Rong; Lou Jinfang; Zhang Fengmin; Luo Jin; Wu Lijun; Yang Huan; Jin Zewu; Xiong Xiaohong; Qian Yang; (32 pag.)CN110156754; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia