Adding a certain compound to certain chemical reactions, such as: 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H5Cl2N3, blongs to pyrimidines compound. HPLC of Formula: C5H5Cl2N3
NH3 (g) was bubbled into EtOH (60 mL) at -40 C for 0.5 h (15 Psi). Then 4,6- dichloro-2-methyl-pyrimidin-5-amine (5 g, 28.09 mmol, 1 eq) was added at 18 C, and the result reaction mixture was stirred at 120 C for 13.5 hr (15 Psi). The reaction mixture was concentrated under reduced pressure to remove EtOH. Compound 6-chloro-2-methyl- pyrimidine -4, 5-diamine (I-791) (5.8g) was obtained as a yellow solid. LCMS m/z 158.8 (M+1)+.
The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SITARI PHARMA, INC.; CAMPBELL, David; CHAPMAN, Justin; CHEUNG, Mui, H.; DIRAIMONDO, Thoams, R.; DURON, Sergio, G.; (615 pag.)WO2020/33784; (2020); A1;,
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