Application of 62968-37-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62968-37-0, name is 4-(2-Chloropyrimidin-4-yl)morpholine, molecular formula is C8H10ClN3O, molecular weight is 199.64, as common compound, the synthetic route is as follows.
General procedure: Compound 12 (0.088g, 0.173mmol), a 2M solution of sodium carbonate (0.520mL, 1.039mmol) in water, tetrakis(triphenylphosphine)palladium(0) (0.014g, 0.012mmol), dimethoxyethane (2mL), ethanol (1.3mL) and the respective morpholine substituted pyrimidine (0.190mmol) were added together and heated to 85C for 12h. The resulting mixture was concentrated under reduced pressure and the product was separated by silica column chromatography (hexanes/ethyl acetate) and purified by reverse phase chromatography (water/acetonitrile).
The chemical industry reduces the impact on the environment during synthesis 62968-37-0, I believe this compound will play a more active role in future production and life.
Reference:
Article; Woodring, Jennifer L.; Bachovchin, Kelly A.; Brady, Kimberly G.; Gallerstein, Mitchell F.; Erath, Jessey; Tanghe, Scott; Leed, Susan E.; Rodriguez, Ana; Mensa-Wilmot, Kojo; Sciotti, Richard J.; Pollastri, Michael P.; European Journal of Medicinal Chemistry; vol. 141; (2017); p. 446 – 459;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia