Electric Literature of 74840-34-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74840-34-9, name is 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid, molecular formula is C6H5ClN2O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2 g (6.6 mmol) of the starting material 1 ‘was dissolved in 10 ml of absolute ethanol,0.68 g of NaOH solid, 10 ml of water,Raise the temperature to reflux.After 1 h, TLC showed complete reaction.Rotate the ethanol, adjust the pH to 3 with 6NHCl,There is a lot of solid precipitation.Extraction can be obtained in white crystals 1.69g, the yield of 91.8percent.
According to the analysis of related databases, 74840-34-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Pharmaceutical University; Xiang, Hua; Lao, Kejing; He, Conghui; Tang, Zhengpu; Yan, Ming; Xiao, Hong; You, Qidong; (14 pag.)CN104356192; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia