Synthetic Route of 582313-57-3, Adding some certain compound to certain chemical reactions, such as: 582313-57-3, name is 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine,molecular formula is C6H3ClFN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 582313-57-3.
To containCCl4 (5 mL, 51 mmol)Add hexamethylphosphoramide to a solution of 5-O-tert-butyldimethylsilyl-2,3-O-isopropylidene-D-ribose (9.13 g, 30 mmol) in toluene (100 mL) 7.2 mL, 40 mmol). After stirring at 0 C for 2.5 hours,The reaction mixture was added to 4-chloro-5-fluoro-7H-pyrrole [2,3-d]pyrimidine (14-1, 3.1 g,20 mmol), a solution of tris(3,6-dioxaheptyl)amine (TDA-1) (3 mL, 9 mmol) and KOH (2.6 g, 4.5 mmol) in toluene (100 mL)The entire reaction mixture was stirred at room temperature for 24 hours.The reaction was terminated by the addition of a saturated aqueous solution of NH 4 Cl.Transfer the entire mixture to a separatory funnel. The aqueous layer is extracted with AcOEt.The combined organic layers were washed with brine.Dry (Na2SO4)Concentration in vacuo gave the crude product 17-2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 582313-57-3, 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Hongyi Biological Technology Co., Ltd.; Wu Rongguang; Yi Dewu; (140 pag.)CN109694397; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia