Adding a certain compound to certain chemical reactions, such as: 84905-80-6, 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine, blongs to pyrimidines compound. Safety of 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine
Into a 20-mL vial was placed 4-chloro-5H-pyrrolo[3,2-d]pyrimidine (250.00 mg; 1.63 mmol), and 4-phenoxyaniline (452.29 mg: 2.44 mmol) suspended in acetonitrile (3.00 ml). The reaction mixture was heated at 100 C overnight. The murky reaction mixture was allowed to cool to rt. The solid was filtered and washed with acetonitrile. The solid was dried under vacuum to afford N-(4-phenoxyphenyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (580.00 mg, 100% yield) as a yellow solid. MS: m/z = 303 [M+H]+.
The synthetic route of 84905-80-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; LIU-BUJALSKI, Lesley; NGUYEN, Ngan; QIU, Hui; JONES, Reinaldo; MOCHALKIN, Igor; CALDWELL, Richard D.; WO2015/17502; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
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