Adding a certain compound to certain chemical reactions, such as: 89466-42-2, 4-Chloro-6-methoxy-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H7ClN2OS, blongs to pyrimidines compound. HPLC of Formula: C6H7ClN2OS
(2) Synthesis of Compound III-29 from the intermediate The compound (IV-29) (19.0 g, 0.100 mol) which was the intermediate obtained in the step (1) above, was dissolved in acetic acid (200 ml), then 31% aqueous hydrogen peroxide (25.2 g, 0.100*2.3 mol) was added, and the solution was heated to 100 C. while stirring. After stirred for 2 hours, the reaction solution was poured into water and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and filtered, and thereafter, the solvent was distilled off to obtain a crude product (20.0 g), which was then purified on silica gel column chromatography (Wakogel C300, 300 ml, ethyl acetate/hexane=400 ml/400 ml) to obtain the compound (III-29) as a white crystalline product from the fraction of 300 ml to 600 ml. Yield: 11.5 g. m.p. 68 to 74 C. 1 H-NMR (60 MHz, CDCl3, delta): 3.30(3H,s), 4.07(3H,s), 6.87 (1H,s).
The synthetic route of 89466-42-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kureha Kagaku Kogyo Kabushiki Kaisha; US5599770; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
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