As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1582-25-8, name is 4-Chloro-6-methyl-2-trifluoromethylpyrimidine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H4ClF3N2
To a mixture of 4-chloro-6-methyl-2-(trifluoromethyl)pyrimidine (2.27 g, 11.5 mmol) in methanol (30 mL) were added Pd(dppf)Cl2 (845 mg, 1.2 mmol) and TEA (11.6 g, 115.5 mmol). The mixture was stirred at 70 C for 16 h under CO atmosphere. The solids were filtered out and the filtrate was concentrated under vacuum. The residue was purified by chromatography to afford the title compound (250 mg, 10%).
With the rapid development of chemical substances, we look forward to future research findings about 1582-25-8.
Reference:
Patent; NURIX THERAPEUTICS, INC.; BARSANTI, Paul A.; BENCE, Neil F.; GOSLING, Jennifa; SAHA, Anjanabha; TAHERBHOY, Asad M.; ZAPF, Christoph W.; BOYLE, Kathleen; CARDOZO, Mario; MIHALIC, Jeffrey; LAWRENZ, Morgan; GALLOP, Mark; BRUFFEY, Jilliane; CUMMINS, Thomas; ROBBINS, Daniel; TANAKA, Hiroko; WANG, Chenbo; COHEN, Frederick; PALMER, Wylie; SANDS, Arthur T.; SHUNATONA, Hunter; (968 pag.)WO2019/148005; (2019); A1;,
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