Electric Literature of 3438-46-8 ,Some common heterocyclic compound, 3438-46-8, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a RBF, dry THF (3 mL) was added followed by DIA (0.158 mL,0.397 mL, 2.78 mmol, 4.2 equiv.). This solution was cooled to 78C and treated with n-BuLi (1.669 mL, 2.72 mmol, 4.1 equiv., 1.6 Min hexane) and stirred for 10 min. To this solution, 2-methylpyridine(0.262 mL, 247 mg, 2.65 mmol, 4 equiv.) was added dropwise.After 30 min, a solution of methyl 2-hydroxy-4-(methoxymethoxy)-6-methylbenzoate (13, 150 mg, 0.663 mmol) was addeddropwise to the pyridine solution. The yellow solution was kept at78 C and allowed to warm to rt over 2 h. The solvent wasremoved under vacuum, and dichloromethane (10 mL) was addedand washed with water (5 mL). The organic layer was dried overMgSO4 and concentrated. The residue was purified on silica (2%MeOH: DCM) to give the MOM-ether as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3438-46-8, 4-Methylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Xu, Qian; Kulkarni, Amol A.; Sajith, Ayyiliath M.; Hussein, Dilbi; Brown, David; Guener, Osman F.; Reddy, M. Damoder; Watkins, E. Blake; Lassegue, Bernard; Griendling, Kathy K.; Bowen, J. Phillip; Bioorganic and Medicinal Chemistry; vol. 26; 5; (2018); p. 989 – 998;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia