Synthetic Route of 42839-08-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42839-08-7, name is Ethyl pyrimidine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.
Mg (0.48 g, 20 mmol) was added to a round-bottomed flask dried at room temperature and I2 (0.2 g) and THF (60 mL) were added under a nitrogen stream.After cooling to 01-Bromo-4-chlorobenzene (3.82 g, 20 mmol) was added slowly and the solution was stirred at room temperature for 2 hours.After cooling to 0 Ethyl pyrimidine-2-carboxylate (1.52 g, 10 mmol)Was dissolved in THF (30 mL) and slowly added to the above solution for 1 h and stirred for 2 h.After completion of the reaction, the reaction mixture was extracted with NH4Cl and ethyl acetate. The organic layer was dried over Na2SO4, concentrated under reduced pressure, and purified by column chromatography (EtOAc / Hexane)The target compound, bis(4-chlorophenyl) (pyrimidin-2-yl) methanol (1.88 g, yield 57%).
According to the analysis of related databases, 42839-08-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Doosan Co., Ltd; Lee Yong-hwan; Kim Hoe-mun; (62 pag.)KR2019/33218; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia