In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42754-96-1, name is 4,6-Dichloro-1H-pyrazolo[3,4-d]pyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines
pTsOH (30.2 mg, 0.159 mmol) was added to a solution of 4,6-dichloro-lH- pyrazolo[3,4-d]pyrimidine (300 mg, 1.587 mmol) and 3,4-dihydro-2H-pyran (200 mg, 2.381 mmol) in a mixture of tetrahydrofuran (ratio: 1 : 1; volume: 5 ml) and (( (ratio: 1 : 1 ; volume: 5 ml). The reaction mixture was stirred for 12 h at room temperature after which the solvent was removed in vacuo. The residue was taken in (( (20 mL) and poured in water (20 ml). The organic phase was separated, the aqueous phase was extracted with CH2CI2 (20 mL), the combined organic phases were washed with water (40 mL) and brine (40 mL) then dried over a2S04 and concentrated. The resulting crude material was purified by flash chromatography (CELCVMeOH 99: 1 increasing) to yield the title compound (397 mg, 1.454 mmol, 92 % yield) as a pale white oil. NMR (400 MHz, CDC13): delta 8.19 (s, 1H), 5.99 (dd, 1H, J = 2.4 & 10.4 Hz), 4.12 (m, 1H), 3.79 (m, 1H), 2.53 (m, 1H), 2.13 (m, 1H), 1.93 (m, 1H), 1.76 (m, 2H), 1.64 (m, 1H). ESI-MS: 273.0 [M+H]+.
The synthetic route of 42754-96-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UNIVERSITY OF UTAH RESEARCH FOUNDATION; VANKAYALAPATI, Hariprasad; SORNA, Venkataswamy; WARNER, Steven, L.; BEARSS, David, J.; SHARMA, Sunil; WO2014/55928; (2014); A2;,
Pyrimidine | C4H4N2 – PubChem,
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