Related Products of 145783-15-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, molecular formula is C7H9Cl2N3S, molecular weight is 238.14, as common compound, the synthetic route is as follows.
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine (0.5 g, 2.1 mmol) was dissolved in methanol (2 mL) and supplemented with sec-butylamine (460.0 mg, 6.3 mmol). The reaction mixture was introduced in a sealed vessel and heated at 100C for 90 min. After concentration of the reaction mixture to dryness under vacuum, the residue was purified by silica gel column chromatography.Yield: 81%.Melting point: liquid.*H NMR (DMSO -d6) d 0.87 (t, J=7.4 Hz, 3H, NHCH(CH3)CH2C/ ,), 0.95 (t, J=7.3 Hz, 3H, SCH2CH2CH3), 1.15 (d, J=6.6 Hz, 3H, NHCH(C/ ,)CH2CH3), 1.53 (m, 2H, NHCH(CH3)CH2CH3), 1.64 (h, J=7.3 Hz, 2H, SCH2CH2CH3), 2.93 (t, J=7.2 Hz, 2H, SCH2CH2CH3), 4.01 (hept, J=6.6 Hz, 1H,NHCH(CH3)CH2CH3), 4.81 (s, 2H, NH2), 6.64 (d, J=7.5 Hz, 1H, NHCH(CH3)CH2CH3).13C NMR (DMSO -d6) d 10.5 (NHCH(CH3)CH2CH3), 13.3 (SCH2CH2CH3), 19.8 (NHCH(CH3)CH2CH3), 22.8 (SCH2CH2CH3), 28.6 (NHCH(CH3)CH2CH3), 32.1 (SCH2CH2CH3), 47.9 (NHCH(CH3)CH2CH3), 119.7 (C-5), 137.3 (C-6), 152.0 (C-4), 155.0 (C-2)
Statistics shows that 145783-15-9 is playing an increasingly important role. we look forward to future research findings about 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine.
Reference:
Patent; UNIVERSITE DE LIEGE; LANCELLOTTI, Patrizio; OURY, Cecile; PIROTTE, Bernard; (140 pag.)WO2019/158655; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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