Reference of 4316-93-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of (lR,3R,4S)-3-(((/er/-butyldimethylsilyl)oxy)methyl)-4-((triisopropylsilyl)oxy)cyclopentan-l -amine (1.05 g, 2.48 mmol) and 4,6-dichloro-5- nitropyrimidine (578 mg, 2.98 mmol) in a mixture of THF (12.5 mL), DMF (6.0mL) and triethylamine (0.88 mL, 6.2 mmol) was stirred at room temperature for 1 hour. The reaction solution was partitioned between saturated aqueous NaHC03(30 mL) and EtOAc (50 mL).Upon separation, the aqueous phase was extracted with additional EtOAc (2×50 mL). The combined organic phases were dried over anhydrous MgS04and concentrated to afford N- i ( 1 R,3R,4S)-3-( i [/tv7-butyl(dimethyl)silyl]oxy }methyl)-4-[(triisopropylsilyl)oxy]cyclopentyl }- 6-chloro-5-nitropyrimidin-4-amine (1.31 g, 94 %) which was carried on to step 2 without further purification. LCMS (FA): m/z = 559.2 (M+H).
According to the analysis of related databases, 4316-93-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; CIAVARRI, Jeffrey; ENGLAND, Dylan Bradley; GIGSTAD, Kenneth M.; GOULD, Alexandra E.; GREENSPAN, Paul; HU, Yongbo; HUANG, Shih-Chung; LANGSTON, Steven Paul; MIZUTANI, Hirotake; SHI, Zhan; VYSKOCIL, Stepan; XU, He; (156 pag.)WO2019/180683; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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