Electric Literature of 461-98-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 461-98-3, name is 2,6-Dimethylpyrimidin-4-amine. A new synthetic method of this compound is introduced below.
2-(2,6-Dimethyl-pyrimidin-4-ylamino)-thiazole-5-carbonitrile (22-3) 4-amino-2,6-dimethylpyrimidine (93 mg, 0.76 mmol)was dissolved in 1.4 mL anhydrous DMF and sodium hydride (66mg, 60% dispersion, 2.77 mmol) was added at room temperature. When the bubbling stopped, 2-chloro-thiazole-5-carbonitrile (0.100 g, 0.692 mmol) was added and the reaction was stirred at room temperature. After 4 hours, 1M HCl was added until the solution was neutral. The resulting precipitate was filtered, washed with water, and dried under high vacuum. The material was washed with hexane and filtered again and air dried to afford the title compound. 1H-NMR (300 MHz, DMSO-d6) 12.47 (1H,s), 8.32 (1H,s), 6.75 (1H,s), 2.58 (3H,s), 2.38 (3H,s). M+1=232.1. MP>250
At the same time, in my other blogs, there are other synthetic methods of this type of compound,461-98-3, 2,6-Dimethylpyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia