Synthetic Route of 3438-61-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3438-61-7, name is 5-Amino-4-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
[00115] To the solution of methyl 4-(5-ethyl-2-(5-methylisoxazol-3-yl)thiazol-4-yl)benzoate (73 mg, 0.22 mmol) in toluene (4 mL) was added 4-methylpyrimidin-5-amine (46 mg, 0.42 mmol) and AlMe3 (2M solution in toluene, 0.21 mL, 0.42 mmol). The reaction was heated in microwave at 110C for 15 min before it was diluted with EtOAc (15 mL) and washed with IN NaOH (25 mL chi 2). The organic phase was dried over magnesium sulfate, filtered, and concentrated. Column chromatography gave Compound 6 in 73% yield. [00116] NMR (400 MHz, CDCls) delta 9.27 (s, 1H), 8.96 (s, 1H), 8.03 – 7.96 (m, 2H), 7.87 – 7.81 (m, 2H), 7.70 (s, 1H), 6.60 (d, / = 1.1 Hz, 1H), 3.07 (q, / = 7.5 Hz, 2H), 2.61 (s, 3H), 2.52 (d, / = 1.0 Hz, 3H), 1.42 (t, / = 7.5 Hz, 3H). ESMS cacld (C21H19N5O2S): 405.1; found: 406.3 (M+H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3438-61-7, 5-Amino-4-methylpyrimidine.
Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHEN, Shoujun; ZHANG, Junyi; JIANG, Jun; KOWALCZYK-PRZEWLOKA, Teresa; XIA, Zhiqiang; ZHANG, Shijie; WO2013/63385; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia