Related Products of 138274-14-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.138274-14-3, name is 5-(Benzyloxy)-2-chloropyrimidine, molecular formula is C11H9ClN2O, molecular weight is 220.66, as common compound, the synthetic route is as follows.
Step 1 In a microwave vial, cis-7-mcthyl-8-((3,4,5-trifluorophcnyl)carbamoyl)-2,3,3a,4,10,10a-hexahydro-lH,7H-dipyrrolo[3,4-b:3′,4′-f][l,4,5]oxathiazocin-2-ium 5,5-dioxide iodide (E11) (20 mg, 0.036 mmol) and 5-(benzyloxy)-2-chloropyrimidine (l5.8 mg, 0.072 mmol) were suspended in 1 -Butanol (0.3mL), dry DIPEA (0.020 mL, 0.115 mmol) was added and mixture heated at l55C under MW for 2 h. The reaction mixture was evaporated under reduced pressure to afford a dark brown solid. The residue was purified by preparative HPLC (H20, CH3CN 0.1% TFA) to afford, after lyophilization 2-(5-(benzyloxy)pyrimidin-2-yl)-7-methyl-N-(3,4,5-trifluorophenyl)-2,3,3a,4,10,10a-hexahydro-lH,7H-dipyrrolo[3,4-b:3′,4′-f][l,4,5]oxathiazocine-8-carboxamide 5,5-dioxide (lOmg, 0.016 mmol, yield= 45%).
Statistics shows that 138274-14-3 is playing an increasingly important role. we look forward to future research findings about 5-(Benzyloxy)-2-chloropyrimidine.
Reference:
Patent; OSPEDALE SAN RAFFAELE S.R.L.; IRBM S.P.A.; PROMIDIS S.R.L.; ISTITUTO NAZIONALE DI GENETICA MOLECOLARE – INGM; DE FRANCESCO, Raffaele; DONNICI, Lorena; GUIDOTTI, Luca; IANNACONE, Matteo; DI FABIO, Romano; SUMMA, Vincenzo; PRANDI, Adolfo; RANDAZZO, Pietro; GORNATI, Davide; GRILLO, Alessandro; FERRANTE, Luca; BENCHEVA, Leda Ivanova; DE MATTEO, Marilenia; FERRARA, Marco; (238 pag.)WO2020/30781; (2020); A1;,
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