Adding a certain compound to certain chemical reactions, such as: 633328-98-0, 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, blongs to pyrimidines compound. Recommanded Product: 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine
In a 50 mL round-bottom flask with a stir bar, 5-chloro-1H-pyrazolo[4,3-d]pyrimidine (Oxchem, 600 mg, 3.88 mmol) and triethylamine (649 mul, 4.66 mmol) were dissolved in CH2Cl2 (12.9 mL). Di-tert-butyl dicarbonate (991 mul, 4.27 mmol) was added, and the reaction mixture was stirred at r.t. for 1 h. The reaction mixture was then diluted with water, extracted with CH2Cl2, and the combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. The crude product was purified by Biotage Isolera (860 mg, 87%). LCMS calculated for C10H12ClN4O2 (M+H)+ m/z=255.1; found 255.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,633328-98-0, 5-Chloro-1H-pyrazolo[4,3-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Incyte Corporation; Vechorkin, Oleg; Liu, Kai; Pan, Jun; Sokolsky, Alexander; Ye, Hai Fen; Ye, Qinda; Yao, Wenqing; Hummel, Joshua; (117 pag.)US2018/72741; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia