Sources of common compounds: 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-34-2, 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.38275-34-2, name is 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid, molecular formula is C6H5ClN2O4S, molecular weight is 236.6329, as common compound, the synthetic route is as follows.Application In Synthesis of 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid

3B. 5-Chloro-2-(methylsulfonyl)pyrimidine 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid (5.7 g, 24 mmol) was refluxed in anisole (8 mL) until the evolution of carbon dioxide ceased. The reaction mixture was cooled to room temperature and filtered. The solid was washed with light petroleum ether (1×50 mL) and dried to obtain the title compound (4.10 g, 88% yield) as a light orange solid. ESI-MS: 193.5 (MH+); HPLC Rf: 1.8 minutes (HPLC method 1); HPLC purity: 100%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-34-2, 5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc; US2007/270438; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia