Related Products of 54-20-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54-20-6, name is 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione, molecular formula is C5H3F3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-trifluoromethyluracil (48.0 g, 267 mmol) is suspended in 210 mL phosphorus oxychloride (POCI3) while moisture is excluded. Diethylaniline (47.7 g, 320 mmol) is slowly added dropwise to this suspension such that the temperature remains between 250C and 300C. After the addition has ended the mixture is stirred for a further 5 – 10 min in the water bath and the mixture is heated for 5- 6 h with the exclusion of moisture at 80 – 900C. The excess POCI3 is destroyed by stirring into approx. 1200 g of sulphuric acid mixed with ice water and the aqueous phase is immediately extracted 3 x with in each case 500 mL diethyl ether or te/t.-butylmethyl ether. The combined ethereal extracts are washed 2 x with 300 mL sulphuric acid mixed with ice water (approx. 0.1 M) and with cold saline solution and immediately dried on sodium sulphate. The desiccant is filtered off and the solvent is eliminated in vacuo. The residue is distilled in vacuo (10 mbar) through a short column (20 cm) (head temperature: 65 – 700C), to obtain a colourless liquid that is bottled and stored under argon. TLC: Rf = 0.83 (chex:EE = 3:1)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54-20-6, 5-(Trifluoromethyl)pyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SAPOUNTZIS, Ioannis; BETZEMEIER, Bodo; STADTMUELLER, Heinz; WO2010/55117; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia