In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51752-67-1, name is 4-Chloropyrido[3,4-d]pyrimidine, the common compound, a new synthetic route is introduced below. 51752-67-1
EXAMPLE 24 (3-Ethynyl-phenyl)-pyrido[3,4d]pyrimidin4-yl-amine To 4-chloro-pyrido[3,4-d]pyrimidine (250 mg, 1.50 mmol) in N-methylpyrrolidin-2-one (0.5 mL) was added 3-ethynylaniline (212 mg, 1.81 mmol) and pyridine (237 mg, 3.0 mmol). The mixture was heated to 80 C. under an atmosphere of dry N2(g) for 3 hours. The reaction mixture was dissolved in CHCl3 and washed with saturated aqueous Na2CO3, and brine. The organic phase was dried over Na2SO4, concentrated in vacuo, and flash chromatographed on silica with a gradient of 40% to 70% acetone/hexanes to afford 120 mg of product. This material was precipitated as its hydrochloride salt by dissolution in minimal CHCl3, titration with HCl (1 eq.) in diethyl ether, and dilution with diethyl ether.
The synthetic route of 51752-67-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARNOLD, LEE DANIEL; MOYER, MIKEL PAUL; SOBOLOV-JAYNES, SUSAN BETH; US2002/45630; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia