Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55583-59-0, blongs to pyrimidines compound. name: 2,5-Diamino-4,6-dichloropyrimidine
To (1 S,4H)-4-amino-2-cyclopentene-1 -methanol tartrate salt (1 g, 4 mmol) in n- BuOH (10 mL) was added 2,5-diamino-4,6-dichloropyrimidine (DADCP, 0.69 g, 4 mmol) and NaHCOs (1 .12 g, 13 mmol) and the mixture was allowed to stir for 16 hr at 95 C. The mixture was cooled and filtered under vacuum. The resulting solvent from the filtrate was removed in vacuo. The crude product was purified by column chromatography (1 :49 to 1 :24 MeOH-DCM) to yield the title compound (0.52 g, 53%) as a pale brown solid, m.p.: 157-159 C (lit. m.p. 158.5- 160.5 C) (29). 1 H NMR (MeOD): delta 5.87 (ddd, J = 5.5, 2.0, 1 .9 Hz, 1 H), 5.80 (ddd, J = 5.6, 2.0, 2.0 Hz, 1 H), 5.07-5.15 (m, 1 H), 3.47-3.56 (m, 1 H), 3.28 (dt, J = 3.2, 1 .6 Hz, 1 H), 2.79-2.83 (m, 1 H), 2.53 (ddd, J= 13.4, 6.4, 6.4 Hz, 1 H), 1 .36 (ddd, J= 13.4, 6.3, 5.9 Hz, 1 H). 13C NMR (MeOD): delta 158.2, 157.3, 143.2, 135.8, 133.9, 1 14.4, 66.4, 57.8, 57.7, 35.8. m/z (ES+) 256.0955 calculated for CioHi5N5035CI: [M+H]+ 256.0965 and 258.0928 calculated for Ci0Hi5N5O37CI: [M+H]+ 258.0936. IR (cm 1): 3451 (N-H), 3324 (N-H), 3125 (br, O-H), 2931 (C-H), 1570 (C=C aromatic), 1430 (CH2), 690 (C-CI).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55583-59-0, its application will become more common.
Reference:
Patent; THE UNIVERSITY OF LIVERPOOL; O’NEILL, Paul; BERRY, Neil; (52 pag.)WO2017/21716; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia