Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56-09-7, name is 2-Amino-6-hydroxypyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below., 56-09-7
1.1 Preparation of 2-Amino-4,6-dichloro-5-pyrimidine Carbaldehyde Phosphorus oxychloride (21.6 ml; 0.236 mol) was cooled in an ice-bath (~5 C.) before slow addition of dry N,N-dimethylformamide (DMF, 7.0 ml) over 15 mins. No precipitate occurred as previously reported, and the reaction mixture was removed from the ice-bath. Commercially available 2-Amino-4,6-dihydroxypyrimidine (5.6 g; 0.044 mol) was added in small portions over 30 mins. The resulting suspension was heated at 90 C. for 1 h, then at 105 C. for a further 5 h. forming a red-brown solution which was chilled at 4 C. overnight. Distillation of 3-4 ml of excess phosphorus oxychloride at atmospheric pressure produced a viscous suspension which was poured into ice-water (100 ml). A gum formed which dissolved as the temperature of the water increased to 20 C. Ammonium hydroxide was added dropwise until the solution reached pH 7 and a yellow precipitate formed which was collected by filtration. The product was recrystallized from ethyl acetate (5.15 g; 0.027 mol; 61%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56-09-7, 2-Amino-6-hydroxypyrimidin-4(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Cancer Research Campaign Technology Limited; US6677345; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia