As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines
Add intermediate IF-1 (12.18g, 31.45mmol) to a 250mL three-necked flask containing THF (100mL), and add n-butyllithium (1.99g, 31.09mmol) dropwise at -78 C. After the dropwise addition, the temperature is maintained for 1h. Trimethyl borate (4.61 g, 44.42 mmol) was then added dropwise, and the temperature was kept at room temperature for 1 h, followed by stirring overnight; hydrochloric acid (2 mol / L) was added to adjust the pH to neutral,After filtration, a white crude product was obtained, which was slurried with n-heptane to obtain a white solid intermediate I-F (7.68 g, yield 70%).
With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.
Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Ma Tiantian; Yang Min; Nan Peng; (69 pag.)CN110615759; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia