Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 591-55-9, name is 5-Aminopyrimidine. A new synthetic method of this compound is introduced below., 591-55-9
General procedure: Ethyl 2-[(2-fluorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate. Diethyl malonate (1.0 mL, 6.6 mmol) was addeddropwise to a solution of sodium hydride (60% w/w in oil, 317 mg,7.9 mmol) in anhydrous tetrahydrofuran (12 mL) that was cooledwith ice bath. The mixture was heated at reflux for 6 min. Aftercooling with ice bath, the reaction mixture was treated dropwisewith chloroacetyl chloride (0.58 mL, 7.2 mmol) and stirred in the icebath for 1 h, and then stirred at 45 C for 1 h. The reaction mixturewas cooled in the ice bath again, and then 2-fluoroaniline (0.76 mL,7.9 mmol) was added dropwise. After stirring at ambient temperaturefor 17 h, the reaction mixture was heated at reflux for 2.5 h.The reaction mixture was allowed to cool to ambient temperature,diluted with aqueous saturated sodium bicarbonate solution, andextracted with ethyl acetate twice and with chloroform. Theorganic layerwaswashed with brine, dried over sodium sulfate andconcentrated. The residue was triturated with ethanol-hexane toafford the title compound as a pale yellow solid (0.58 g, 33%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,591-55-9, 5-Aminopyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Irie, Takayuki; Asami, Tokiko; Sawa, Ayako; Uno, Yuko; Hanada, Mitsuharu; Taniyama, Chika; Funakoshi, Yoko; Masai, Hisao; Sawa, Masaaki; European Journal of Medicinal Chemistry; vol. 130; (2017); p. 406 – 418;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia