Related Products of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A mixture of 2-hydroxynaphthalene-1,4-dione (0.17 g, 1 mmol), 4-chlorobezaldehyde(0.14 g, 1 mmol), 6-amino-uracil (0.12 g, 1 mmol), and p-TSA (0.05 g) in refluxing water (5 mL) was stirred for 6 h. After completion of the reaction as confirmed by thin-layer chromatography (TLC) (eluent EtOAc=n-hexane, 1:3), the reaction mixture was cooled to room temperature. The precipitated product was separated by filtration, washed three times with water and 5mL acetone, and dried at 60?70 ¡ãC. Corresponding products were analytically pure without recrystallization.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,873-83-6, its application will become more common.
Reference:
Article; Azizian, Javad; Delbari, Akram Sadat; Yadollahzadeh, Khadijeh; Synthetic Communications; vol. 44; 22; (2014); p. 3277 – 3286;,
Pyrimidine | C4H4N2 – PubChem,
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