Electric Literature of 53557-69-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 53557-69-0 as follows.
To a solution of 6-iodopyrimidin-4-amine (442 mg, 2 mmol) in 5 mL of DMF was added (Phen)CuCF2CF3 (1.14 g, 3 mmol, purchased from Aspira scientific). The mixture was stirred at 90 C for 2 hours. Then, the mixture was poured into water and extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel to give 6-(1 , 1 ,2,2,2- pentafluoroethyl)pyrimidin-4-amine. H NMR (400Mz, DMSO-c/6) delta (ppm): 6.80 (s, 1 H), 7.50(s, 2 H), 8.47 (s, 1 H). 9F-NMR (300Mz, DMSO-c/6) delta: -79.41 (s, 3 F), -1 16.10 (s, 2 F); ESI-MS(+): 214(M+1 ), ESI-MS(-): 212(M-1 ).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,53557-69-0, its application will become more common.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; EDMUNDS, Andrew; JEANGUENAT, Andre; JUNG, Pierre Joseph Marcel; MUEHLEBACH, Michel; (150 pag.)WO2016/71214; (2016); A1;,
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