Synthetic Route of 62968-37-0 ,Some common heterocyclic compound, 62968-37-0, molecular formula is C8H10ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a solution of 2-chloroheteroaryl compound 1 (0.50 mmol) in 1,4-dioxane (4.0 mL) were added pinacol boronate 3, 5, or 7 (0.60 mmol), Pd(OAc)2 (1.1 mg, 5.0 mumol), S-Phos (4.1 mg, 10.0 mumol), and 2 M LiOH solution (1.0 mL, 2.0 mmol) at room temperature, and the mixture was stirred for 30 min at 80 C under N2 atmosphere. The reaction was quenched by adding water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed in vacuo, and the residue was purified by silica-gel column chromatography. The solvent was removed in vacuo, and the residue was triturated with Et2O to give biaryl compounds.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Asano, Shigehiro; Kamioka, Seiji; Isobe, Yoshiaki; Tetrahedron; vol. 68; 1; (2012); p. 272 – 279;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia