Synthetic Route of 684220-30-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 684220-30-2, name is 4,6-Dichloropyrimidine-2-carboxylic acid, molecular formula is C5H2Cl2N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
As shown in Scheme 3, a sealed pressure bottle containing compound 15(Aldrich, 1 g, 5.2 mmol), compound 16 ( 1.62 g, 5.4 mmol), PdCl2(PPh3)2 (290 mg, 0.41 mmol), and Cs2C03 (3.4 g, 10.4 mmol) in DME ( 16 mL), ethanol (8 mL), and H20 (16 mL) was heated at 60C for 3 h. After cooling, the mixture was diluted with EtOAc (200 mL) and brine (100 mL). After separation, the organic layer was dried with a2S04, filtered, and concentrated under reduced pressure to give compound 17 as yellow solid.
According to the analysis of related databases, 684220-30-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PURDUE PHARMA L.P.; SHAO, Bin; WO2013/72758; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia