Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 698-29-3, name is 4-Amino-2-methylpyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., 698-29-3
EXAMPLE 5 4-Amino-2-methyl-5-pyrimidinecarboxamidoxime A solution of hydroxylamine base, prepared from hydroxylamine hydrochloride (7.296 g., 0.105 mole) and potassium t-butoxide (11.783 g., 0.105 mole) in dimethyl sulfoxide (200 ml.) in a manner similar to that of Example 1, is allowed to react with 4-amino-2-methyl-5-pyrimidine carbonitrile (13.414 g., 0.100 mole). After addition of dimethyl sulfoxide (50 ml.), the mixture is heated at 40+-1 C. for 92 hours. The solid which separates is collected by filtration, successively washed with methanol (1*50 ml.) and water (3*50 ml.) then dried at 110/0.1 mm. The yield of colorless crystals melting at 263 C. dec. (uncorr.) is 10.059 g. (60.2%). A second crop is obtained by concentrating the combined filtrates in vacuo to give a white solid. This material is washed with water, dried at 110 C./0.1 mm. The yield of colorless crystals melting at 256 C. dec. (uncorr.) is 6.300 g. (37.6%). The total yield of crude product is 16.359 g. (97.8%). The combined fractions are recrystallized from 2-methoxyethanol (Darco G-60) affording 7.887 g. (47.2%) of colorless prisms melting at 264 C. dec. (uncorr.). Concentration of the mother liquors yields a second crop of colorless prisms melting at 265 C. dec. (uncorr.) in a yield of 6.258 g. (37.4%) total yield is 14.145 g. (84.6%). Analysis for: C6 H9 N5 O; Calculated: C, 43.11; H, 5.42; N, 41.90; Found: C, 43.04; H, 5.35; N, 42.12.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,698-29-3, 4-Amino-2-methylpyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; American Home Products Corporation; US4323681; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia