Reference of 923282-64-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 923282-64-8, name is 7-Chloro-1H-pyrazolo[4,3-d]pyrimidine. A new synthetic method of this compound is introduced below.
Compound 66: 37 (0.67 g, 2.0 mmol) was added to a solution containing 28 (0.67 g, 2.0 mmol) and Hunig’s base (1.4 mL, 8.0 mmol) in DMF (15 mL). The reaction mixture was heated to 100 C. for 1 hour. The reaction was cooled to room temperature. The reaction mixture was diluted with H2O. Extracted the aqueous layer with EtOAc. Combined the organics, dried with MgSO4, filtered, and concentrated. The crude residue was purified by column chromatography on silica gel using 10% MeOH in DCM to afford 66 (0.45 g, 54%), ES (+) MS m/e=416 (M+1).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,923282-64-8, its application will become more common.
Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2007/27166; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia