Electric Literature of 76044-36-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.76044-36-5, name is 5-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine, molecular formula is C5H3ClN4, molecular weight is 154.56, as common compound, the synthetic route is as follows.
A solution of 155 mg (1 mmol) of 5-chloro[l,2,4]triazolo[l,5-c]pyrimidine [D. J. Brownand K. Shinozuka, Aust. J. Chem., 33., 1147 (1980)] in 6 mL of dry ethanol was added gradually to avigorously stirred solution of 198 mg (204 mg, 4 mmol) of hydrazine monohydrate in 2 mL of dryethanol. A white precipitate separated during the addition. After 1.5 h, the solid was collected on afilter. It was suspended in 2 mL of concentrated ammonium hydroxide and agitated for a few minutes.The solid was then collected on a filter and washed with some additional concentrated ammoniumhydroxide, then with some ethanol, and finally with a large volume of diethyl ether. After drying, thetitle compound was obtained as a white solid, mp 245-246 C (decomposition). LC-MS 151 (M+l).
Statistics shows that 76044-36-5 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine.
Reference:
Patent; MERCK & CO., INC.; WO2006/23750; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia