Sources of common compounds: 7H-Pyrrolo[2,3-d]pyrimidine

The synthetic route of 271-70-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 271-70-5, name is 7H-Pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 271-70-5

A mixture of ethyl 2-(6-bromo-2-(4-methoxybenzyl)-3-oxoisoindolin-1-yl)acetate (3, 439 mg, 1.05 mmol), 7H-pyrrolo[2,3-d]pyrimidine (4, 125 mg, 1.05 mmol), tris(dibenzylideneacetone)dipalladium(0) (97 mg, 0.10 mmol), XantPhos (61 mg, 0.10 mmol), and cesium carbonate (752 mg, 2.31 mmol) in 1,4-dioxane (25 mL) was purged with argon for 5 min. The reaction was stirred at 110 C. for 16 h. Upon cooling, the reaction mixture was diluted with ethyl acetate, washed with half saturated aqueous sodium bicarbonate solution, and then with brine. The organic layer was dried over magnesium sulfate, filtered and concentrated. The crude product was purified via column chromatography (silica, methanol/dichloromethane gradient from 0-5% to afford ethyl 2-(2-(4-methoxybenzyl)-3-oxo-6-(7H-pyrrolo[2,3-d]pyrimidin-7-yl)isoindolin-1-yl)acetate (5). Yield: 333 mg, 70%; MS (ESI) m/z 457.4[M+1]+.

The synthetic route of 271-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; EFFECTOR THERAPEUTICS, INC.; Sprengeler, Paul A.; Reich, Siegfried H.; Ernst, Justin T.; Webber, Stephen E.; (55 pag.)US2017/121339; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia