Related Products of 271-70-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 271-70-5 as follows.
To a stirred solution of 7H-pyrrolo[2,3-d]pyrimidine (11.5 g, 73.92 mmol) in DMF (350 mL) was added a solution of bromine (11.8 g, 73.84 mmol) in DMF (50 mL) at 0C. The cooling bath was removed and the reaction stirred at 20C for 8h, then the reactionmixture was poured into ice-water and basified with Na2CO3. The mixture was extracted with ethyl acetate. The combined organic layers were washed with 10% aq. Na25203 solution, brine, dried over Mg504, the solids were removed by filtration, and the filtrate was concentrated under reduced pressure to afford 16, 5-bromo-7H-pyrrolo- [2,3-d]pyrimidine as yellow solid, used in the next step without further purification. 1H NMR(400 MHz, DMSO-d6) 6 ppm 7.84 (s, 1 H), 8.84 (s, 1 H), 8.92 (s, 1 H), 12.57 (br, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,271-70-5, its application will become more common.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; JONCKERS, Tim Hugo Maria; MC GOWAN, David Craig; GUILLEMONT, Jerome Emile Georges; COOYMANS, Ludwig Paul; EMBRECHTS, Werner Constant Johan; BUYCK, Christophe Francis Robert Nestor; BALEMANS, Wendy Mia Albert; RABOISSON, Pierre Jean-Marie Bernard; (34 pag.)WO2017/89518; (2017); A1;,
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