Related Products of 935667-50-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 935667-50-8 as follows.
To a -60 C solution of Example 361.0 (2.20 g, 6.3 mmol) in THF (13 mL) was added n-butyllithium (2.5 M solution in hexanes, 2.72 mL, 6.8 mmol) slowly via syringe. After 10 mm, a solution of Example 343.2 (660 mg, 5.2 mmol) in THF (5 mL) was added dropwise via cannula at-60 C. The resulting mixture was stirred at -60 C for 15 mm and was then allowed to warm to RT and stirred overnight. The reaction was quenched with saturated aqueous NH4C1 and extracted with EtOAc (3X). The combined organic layers were dried over anydrous sodium sulfate, filtered, and concentrated. The residue was purified by silica gel chromatography (eluent was 20-70% EtOAc in hexanes over 30 mm) to provide Example 355.01 (547 mg, 22% yield) as a red solid. LCMS-ESI (pos.) m/z: 498.0 (M+Na).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,935667-50-8, its application will become more common.
Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
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