Sources of common compounds: (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate.

Related Products of 131860-97-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate. This compound has unique chemical properties. The synthetic route is as follows.

Dimethylacetamide (DMAA, 400ml), 2-Cyanophenol (0.2M, 28g) and NaOH (0.225M, 9g) were placed at ambient temperature into the three-necked IL flask equipped with stirrer, condenser and thermometer. Half the amount of DMAA containing water traces was distilled at vacuum 20mbar/60-65C and the mixture was kept at vacuum 20mbar/ room temperature for Ih. The same amount of prime DMAA was added and Compound (I) (0.2M, 64g) was fed into the flask.The reaction mixture was heated to 100 C and kept at these conditions for 5 hours (monitored by HPLC – conversion of Compound (I) to Azoxystrobin 98-99%).DMAA was distilled at vacuum 20mbar/65-70C. At the end of the distillation the temperature can be increased up to 90-100C.40Og Butylacetate (BuAc) and 20Og water were added to the reaction mixture at 50-60C, the temperature was increased to 80C and stirred 10-15min. The water phase was separated at 800C to remove DMAA traces and inorganic salts.For crystallization the BuAc phase was slowly cooled from 800C to -5C. Filtration was done using filter No.2. The cake was washed with 60 ml cooled Butylacetate or methanol and further dried in oven at 80C during 15 hours. Azoxystrobin with purity 98-99% and a yield of 90-92% was obtained.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 131860-97-4, (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate.

Reference:
Patent; MAKHTESHIM CHEMICAL WORKS LTD.; WO2008/75341; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia