Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1436686-17-7, name is Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Ethyl 5-bromopyrazolo[1,5-a]pyrimidine-3-carboxylate
General procedure: To a solution of 2.8 g (1 1 mmol) compound 1 -11 hydrogen chloride salt and 2.9 g (1 1 mmol) of compound 2 in 50 imL of EtOH was added 4.35 g (43.1 mmol) of EtaN. The mixture was stirred at 90 C for 2 h under nitrogen atmosphere and cooled to rt. It was concentrated under reduced pressure to afford a residue, which was purified by chromatography on silica gel column eluting with 20 % of ethyl acetate in petroleum ether to afford compound 1 -12. LC- MS: m/e = 416 [M+H]+.
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Reference:
Patent; ANGEX PHARMACEUTICAL, INC.; WU, Wen-Lian; YANG, Zhiqiang; LEE, Francis; TAN, John Qiang; (112 pag.)WO2019/94143; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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