As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1197193-30-8, name is Ethyl 5-bromopyrimidine-2-carboxylate, molecular formula is C7H7BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C7H7BrN2O2
To a suspension of the ethyl 5-bromopyrimidine-2-carboxylate (700 mg, 3 mmol), 4,4,5,5-tetramethyl-2-(prop-l-en-2-yl)-1,3,2-dioxaborolane (1.5 g, 9 mmol), andK2C 0 3 (2.1 g, 15 mmol) in DMF (5 mL) and water (1 mL), was added Pd(dppfC12) (250 mg, 0.3 mmol). The resulting mixture was degassed (N2) for 2 min and then heated to heated to 120 C. for 1 h. After cooling to room temperature,the reaction mixture was diluted with MeOH and filteredthrough celite. The filtrate was used directly for next step. MS: (ES) m/z 165.2 (M+H+).
With the rapid development of chemical substances, we look forward to future research findings about 1197193-30-8.
Reference:
Patent; ChemoCentryx, Inc.; Fan, Junfa; Krasinski, Antoni; Lange, Christopher W.; Lui, Rebecca M.; McMahon, Jeffrey P.; Powers, Jay P.; Zeng, Yibin; Zhang, Penglie; US2014/154179; (2014); A1;,
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