Synthetic Route of 51953-18-5, Adding some certain compound to certain chemical reactions, such as: 51953-18-5, name is Pyrimidin-4-ol,molecular formula is C4H4N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51953-18-5.
(b) 4, [5-DICHLOROPYRIMIDINE.] A solution of the pyrimidin-4-one from step (a) above (3.5 g, 26.8 mmol) in phosphorus oxychloride (50 mL) was heated under for 3 h. The reaction mixture was cooled to room temperature, the solvent was evaporated [IN VACUO] and the residue was dissolved in EtOAc (100 mL). The organic solution was washed with saturated aqueous solution of NaHC03 (50 mL) and brine [(50] mL), dried over [NA2S04,] filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography, eluting with 10% [ETOAC/HEXANE,] to give the title compound as an orange oil. MS (ESI, pos. [ION) M/Z] : 131 [(M+1).]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 51953-18-5, Pyrimidin-4-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia