H2-Antihistaminics, XVIII. 5,6-Alkyl-4-pyrimidones with H2-antihistaminic activity was written by Spengler, Jan Peter;Schunack, Walter. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1984.Synthetic Route of C7H10N2OS The following contents are mentioned in the article:
2-[[2-[[(5-Methyl-4-imidazolyl)methyl]thio]ethyl]amino]-4(3H)-pyrimidinones (I)(R = H or Me through octyl, R1 = H; R = H or Me through pentyl, R1 = Me; R = H, R1 = Et) were prepared The antihistaminic activity of I increased with chain length, reached a maximum (almost 10 times that of metiamide) for R = Bu, R1 = H, and slowly declined thereafter. This study involved multiple reactions and reactants, such as 5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3Synthetic Route of C7H10N2OS).
5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (cas: 39083-15-3) belongs to pyrimidine derivatives. Heterocyclic compounds bearing the pyrimidine core are of tremendous interest as they constitute an important class of natural and synthetic compounds exhibiting diverse useful biological activities that hold attractive potential for clinical translation as therapeutic agents in alleviation of a myriad of diseases. Therapy for fungal infections is based mainly on four classes of antifungals: azoles, echinocandins, polyenes, and pyrimidine analogs.Synthetic Route of C7H10N2OS
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia