In 2013,Nature Communications included an article by Srinivasan, Prakash; Yasgar, Adam; Luci, Diane K.; Beatty, Wandy L.; Hu, Xin; Andersen, John; Narum, David L.; Moch, J. Kathleen; Sun, Hongmao; Haynes, J. David; Maloney, David J.; Jadhav, Ajit; Simeonov, Anton; Miller, Louis H.. Computed Properties of C23H22N4O. The article was titled 《Disrupting malaria parasite AMA1-RON2 interaction with a small molecule preventserythrocyte invasion》. The information in the text is summarized as follows:
Plasmodium falciparum resistance to artemisinin derivatives, the first-line antimalarial drug, drives the search for new classes of chemotherapeutic agents. Current discovery is primarily directed against the intracellular forms of the parasite. However, late schizont-infected red blood cells (RBCs) may still rupture and cause disease by sequestration; consequently targeting invasion may reduce disease severity. Merozoite invasion of RBCs requires interaction between two parasite proteins AMA1 and RON2. Here we identify the first inhibitor of this interaction that also blocks merozoite invasion in genetically distinct parasites by screening a library of over 21,000 compounds We demonstrate that this inhibition is mediated by the small mol. binding to AMA1 and blocking the formation of AMA1-RON complex. Electron microscopy confirms that the inhibitor prevents junction formation, a critical step in invasion that results from AMA1-RON2 binding. This study uncovers a strategy that will allow for highly effective combination therapies alongside existing antimalarial drugs. In the experiment, the researchers used many compounds, for example, 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8Computed Properties of C23H22N4O)
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(cas: 213743-31-8) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Computed Properties of C23H22N4O
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia